Glutaraldehyde와 Formaldehyde가 齒髓組織 損傷後 治癒에 미치는 影饗에 對한 實驗的 硏究
Experimental Study of the Effects of Glutaraldehyde and Formaldehrde in Healing of Dental Pulp Tissue following Coronal Amputation.
소속 상세정보
최재홍(崔在弘)/Jae-Hong Choi
차문호(車文豪)/Moon-Ho Cha
KMID : 0358919850120010053
Abstract
結論
健康한 成犬 4마리의 上下顎 左右 犬齒와 小日齒 64個 齒牙에 4가지 濃度의
glutaraldehyde(2%, 5%, 10%, 20%)와 formocresol을 使用하여 生活齒髓切斷術式을 施行한
後, 1週, 2週, 5週, 10週經過後의 殘存齒 髓組織의 病理組織學的 變化를 顯徵鏡으로 觀察하여
다음과 같은 結論을 얻었다.
1. Formocresol群과 2%, 5%, 10% glutaraldehyde 群의 1週經過例에서 齒髓組織의 變化像
은 類似하였다.
2. Formocresol群 2週, 5週, 10運經過 齒髓組織에서 退行性 變性이 점차 齒根端部位로 移
行되는 것이 觀察되었으나 2%, 5%, 10% glutaraldehyde群의 齒髓組織은 齒根管上部에서 退
行性 變性이 나타났으며, 根端部에서는 正常的인 齒髓組織이 觀察되었다.
3. 10週經過例에서 formocresol群과 20% glutaraldehrde群에서 造象牙細胞層이 大部分 損
傷 및 喪失되었으나, 2%, 5%, 10% glutaraldehrde群의 根端部에서는 比較的 正常駒인 排列
을 보였다.
4. 10週經過例에서 formoeresol群과 glutaraldehyde群에서 石灰化物質의 形成은 觀察되지
않았으며, 象牙質吸收像은 formocresol群 그리고 g1utaraldehyde群에서 觀察되었다.
5. glutaraldehyde群에서 濃度增加에 따른 炎症反應과 退行性 變性에는 큰 差異가 없었으
나, 凝固層의 形成은 20% glutaraldehyde群에서 가장 크게 나타났다.
#초록#
The purpose of this study was to evaluate the palpal response against formocresol
and various concentrations of glutaraldehyde (2%, 5%, 10%, 20%). The experiment was
performed on dog’s teeth (64 teeth from 4 dogs) and the teeth were rountinely treated
in laboratory procedures. Histologic examinations of pulp tissue reaction were observed
at various time intervals(1, 2, 5, 10 weeks).
Followings are the results obtained through microscopical examination.
1. The reactions and changes of pulp tissue were similar in formocresol group, and in
2%, 5%, 10% glutaraldehyde groups within 1 week.
2. According to the time increase after experiment, there was seen the prgression of
degenerative changes toward the apical third in formocresol group, and in 2%, 5%, 10%
glutaraldehyde group degenerative changes was seen in the coronal third, but normal
pulp tissue in the apical third.
3. In formocresol group and 20% glutaraldhyde group, the odentoblastic layer was
damaged and destructed, but there was good odontoblastic layer in 2%, 5%, 10%
glutaraldehyde group at the apical third of 10 weeks.
4. In formaocresol group and glutareldehyde group, the formation of dentin bridge was
not seen, but the resorption of dentin was seen in the formocresol group and in the
glutaraldehyde groups of 10 weeks.
5. In glutaraldehyde groups there was no differences in inflammatory reactions and
degenerative changes, but 20% glutaraldehyde group showed the thickest fixed pulp
tissue.
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